LifestyleExcess niacin may increase the risk of heart attack and stroke. ...

Excess niacin may increase the risk of heart attack and stroke. Vitamin B3 Overdose Linked to Increased Heart Disease Risk | . News

More than 1,100 people were included in the study. Scientists discovered that when there is too much niacin in the body, it forms two molecules called 2PY and 4PY. The study also found that the higher the level of these two molecules, the greater the risk of heart disease.

What is Vitamin B3? What is Vitamin B3?

Vitamin B3, also known as niacin, is essential for various body functions. It is a part of the water-soluble vitamin B-complex. It is found in two forms: nicotinic acid and nicotinamide. Both of these forms are converted in the body to the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). These coenzymes play important roles in cells’ metabolism, energy production, and DNA repair.

What is Vitamin B3 found in? What is Vitamin B3 found in?

Niacin is found in abundance in meat, poultry, fish, nuts, seeds and fortified cereals. Additionally, the body can also manufacture niacin from the amino acid tryptophan, although it is not always enough to meet the body’s needs.

What can happen due to Vitamin B3 deficiency? What can happen due to Vitamin B3 deficiency?

Deficiency of Vitamin B3 can cause a disease called pellagra. Its symptoms include skin problems, diarrhea, dementia and, in severe cases, even death. Pellagra used to be common in populations with diets dependent on maize, because maize does not contain enough niacin.

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Vitamin B3 and heart relationship

Niacin supplements have been used to treat hyperlipidemia, as it helps lower LDL cholesterol and increase HDL cholesterol. But, excessive amounts of Niacin can cause flushing, itching and liver damage.

The results of the study suggest that niacin or vitamin B3 may be a new risk factor for heart diseases. Dr. Stanley Hazen, lead researcher of the study, says, “It is now clear why, despite reducing cholesterol, niacin does not provide as much benefit as was expected. This suggests that more Niacin also has some disadvantages in large amounts.”

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