LifestyleScientists find treatment for blindness due to old age, read here

Scientists find treatment for blindness due to old age, read here

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New Delhi . Neovascular age-related macular degeneration (AMD) is a leading cause of blindness. American scientists have developed a possible antibody treatment for this.

Macular degeneration is an eye disease in which the normal structure of the macula is affected.

Aging, diabetes, obesity and many other chronic metabolic diseases cause excessive vascular growth and damage to the macula, the part of the eye that converts light into image signals.

“Typically, anti-VEGF therapy blocks vascular endothelial growth factor and prevents excessive blood vessel growth,” said the team from the Medical College of Georgia (MCG). However, it is successful only for about one third of patients.

They found that the cause was “fibroblast cells”.

“Collagen and several other proteins produced by these fibroblast cells accumulate outside the vascular cells and eventually cause fibrosis, or scarring, in the eye,” according to the study in the journal Science Translational Medicine.

“In this study, we show for the first time that many fibroblast cells are actually produced by these highly endothelial cells,” said Yuqing Huo, director of the Vascular Inflammation Program in MCG’s Center for Vascular Biology.

To prevent this from happening, the team targeted receptor 2A (Adora2A).

Although important in controlling inflammation, increased myocardial oxygen consumption and excess adenosine in coronary blood flow can cause excessive blood vessel enlargement.

For this research, American scientists used rats that had developed fibrosis in the back part of their eyes. Mice were given ‘Adora2A’, which binds to the receptor and blocks its function. The team said that a reduction in fibrosis was subsequently observed in the eyes of the mice.

“An antibody can actually prevent both excessive blood vessel growth in the early stages of AMD and fibrosis in the late stages of AMD,” Huo said. “Our findings indicate that blocking Adora2A could potentially target multiple stages of this disease in a way that may be more efficient than current treatments.”


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