LifestyleSome diabetes medicines can reduce the risk of kidney stones.

Some diabetes medicines can reduce the risk of kidney stones.

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New York. Some diabetes medications can reduce the risk of kidney stones. While type 2 diabetes is associated with an increased risk of kidney stones, some types of treatment for the condition may also have benefits in reducing the risk of kidney stones, according to a study.

Researchers at Brigham and Women’s Hospital and Massachusetts General Hospital in the US found that there was an association between the use of sodium-glucose contratransporter 2 (SGLT2) inhibitors and a reduced risk of developing kidney stones.

The study, reported in JAMA Internal Medicine, included data from three nationwide US databases of patients with type 2 diabetes who were seen in routine clinical practice.

The team analyzed information from 716,406 adults with type 2 diabetes. who had started taking SGLT2 inhibitors or two other classes of diabetes drugs known as GLP1 receptor agonists or dipeptidyl peptidase 4 (DPP4) inhibitors.

Patients who started taking SGLT2 inhibitors had a 30 percent lower risk of developing kidney stones than those taking GLP1 agonists, and about 25 percent lower than those taking DPP4 inhibitors.

These findings were consistent across gender, race/ethnicity, history of chronic kidney disease, and obesity.

“Our findings may help inform routine decision-making for patients with diabetes who are at risk for kidney stones,” said corresponding author Julie Pike, of the Department of Pharmacoepidemiology and Pharmacoeconomics at Brigham and Women’s Hospital.


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